Ionis Pharmaceuticals Inc. (IONS)$75.56
Market Cap: 5.35 BCurrency: USD
Research Snapshot
Static fundamentals, valuation context, and investor signals for Ionis Pharmaceuticals Inc. (IONS).
HEALTHCARE
BIOTECHNOLOGY
DCF ready
Valuation
-21.2x
EV/FCF, N/A FCF yield
Quality
-16.6%
ROIC, -33.9% FCF margin
Growth
5.3%
5Y sales (revenue) CAGR
Balance sheet
3.7x
Debt/equity, 3.8x current ratio
Superinvestors
1
Top: Tweedy Browne Co. (13.6%)
Strengths to research
- 10 annual periods are available for trend analysis.
Watchouts
- Free cash flow margin is negative at -33.9%.
- Debt/equity is high at 3.7x.
Annual data: 10 periods
Quarterly data: 24 periods
Stock snapshot: May 25, 2026
Static dataset: May 25, 2026
Quality Scorecard
Build-time composite score for IONS.
Grade F
12
/ 100
Peer Comparison
Target stock against 8 market-cap comparable peers.
Heat map: red worst to green best
| IONS Target | Ionis Pharmaceuticals Inc. | $5.4B | -31.7x | -21.2x | -16.6% | 5.3% | -33.9% | N/A | N/A | N/A |
| AXSM | Axsome Therapeutics Inc. | $5.7B | -64.1x | -57.1x | -207.5% | N/A | -14.7% | N/A | N/A | N/A |
| LEGN | Legend Biotech Corp. | $6.1B | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| PCVX | Vaxcyte Inc. | $4.4B | -8.4x | -6.3x | -0.0% | N/A | N/A | N/A | N/A | N/A |
| BBIO | BridgeBio Pharma Inc. | $7.3B | -18.3x | -19.5x | N/A | 127.4% | -89.0% | N/A | N/A | N/A |
| HALO | Halozyme Therapeutics | $7.5B | 26.7x | 14.7x | 14.5% | 39.2% | 46.2% | N/A | 4.2x | N/A |
| TECH | Bio-Techne Corp. | $7.9B | 104.8x | 30.1x | 3.8% | 10.5% | 21.0% | 64.8% | -0.8x | N/A |
| ROIV | Roivant Sciences Ltd | $8.3B | -55.5x | -9.0x | -6.6% | -19.1% | -9183.5% | N/A | N/A | N/A |
| MRNA | Moderna, Inc. | $10.8B | -6.5x | -4.0x | -32.6% | 19.3% | -106.2% | N/A | N/A | N/A |
Financial Charts
No financial data available for IONS (annual).
1 superinvestors own IONS
Current quarter ownership and quarter-over-quarter share changes.
Superinvestor ownership
| Fund | Shares | Value | % Portfolio | QoQ Change |
|---|---|---|---|---|
| Tweedy Browne Co. Tweedy Browne Value Fund | 2,275,625 | $171M | 13.57% | 0.0% |